MOTS-c is a small protein produced in the mitochondria — the so-called powerhouses of our cells — and plays an important role in regulating energy metabolism. It influences how the body processes glucose and responds to insulin, thereby contributing to a healthy metabolic balance. MOTS-c migrates to the cell nucleus, where it regulates genes associated with energy production and stress response — particularly when the body is under metabolic stress. Research suggests that MOTS-c may improve glucose control, support metabolism, and be beneficial in age-related health conditions. There is also evidence that it promotes metabolic homeostasis and longevity, enhances exercise performance, and may counteract obesity, insulin resistance, and conditions such as osteoporosis.

MOTS-c is a mitochondrial-derived peptide (MDP) consisting of 16 amino acids that plays a key role in cellular metabolic regulation. It is produced in the mitochondria and helps maintain energy balance — in part through signaling pathways involved in glucose metabolism, insulin sensitivity, and cellular stress responses. MOTS-c functions by migrating to the cell nucleus, where it influences genes important for the formation of new mitochondria as well as for the regulation of metabolism, particularly during times of metabolic stress. Research shows that this peptide may enhance physical performance, reduce obesity and insulin resistance, and counteract conditions such as osteoporosis. In addition, it may help alleviate metabolic disorders and age-related health issues. Overall, MOTS-c supports metabolic homeostasis and longevity, improves exercise capacity, and has beneficial effects on various aspects of health.